Menadiol sodium diphosphate
Kappadione, Synkayvite (menadiol sodium diphosphate) is a small molecule pharmaceutical. Menadiol sodium diphosphate was first approved as Kappadione on 1982-01-01.
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | 6 | 10 | 8 | 20 | 44 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | 6 | 2 | 7 | 15 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | 3 | 7 | 1 | 5 | 14 |
| Thrombosis | D013927 | — | — | 1 | 4 | 5 | 1 | 1 | 12 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | — | 1 | 4 | 3 | 3 | 10 |
| Venous thrombosis | D020246 | — | I82.40 | 1 | 3 | 4 | 1 | 2 | 10 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | 2 | 1 | 1 | 4 |
| Atrial flutter | D001282 | EFO_0003911 | — | — | 1 | 2 | 1 | — | 3 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | 1 | 1 | — | 2 |
| Hematoma | D006406 | EFO_0010680 | — | — | — | 1 | 1 | — | 2 |
Show 14 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | 2 | 1 | 6 | — | 6 | 14 |
| Thromboembolism | D013923 | — | — | — | — | 7 | — | 2 | 9 |
| Embolism | D004617 | — | — | 1 | — | 3 | — | 2 | 6 |
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | — | — | 2 | — | 2 | 4 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 2 | 2 | — | 1 | 4 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | 1 | — | 2 | 3 |
| Heart valve diseases | D006349 | EFO_0009551 | I08 | — | 2 | 1 | — | 1 | 3 |
| Neoplasms | D009369 | — | C80 | 2 | — | 1 | — | — | 3 |
| Hemostatic disorders | D020141 | — | — | — | 1 | 2 | — | — | 2 |
| Hypertensive intracranial hemorrhage | D020299 | — | — | — | — | 1 | — | 1 | 2 |
Show 23 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | 1 | — | — | 5 | 12 |
| Cerebral hemorrhage | D002543 | — | — | — | 1 | — | — | 1 | 2 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 1 | — | — | — | 2 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | 1 | — | — | 1 | 2 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | 1 | — | — | 1 | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | 1 | — | — | — | 1 |
| Chronic pancreatitis | D050500 | EFO_0000342 | K86.1 | — | 1 | — | — | — | 1 |
| Exocrine pancreatic insufficiency | D010188 | — | K86.81 | — | 1 | — | — | — | 1 |
| Hypercholesterolemia | D006937 | — | — | — | 1 | — | — | — | 1 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | 1 | — | — | — | 1 |
Show 4 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | 3 | — | — | — | — | 3 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 2 | — | — | — | — | 2 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 2 | — | — | — | — | 2 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 1 | — | — | — | — | 1 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | 1 | — | — | — | — | 1 |
| Crohn disease | D003424 | EFO_0000384 | K50 | 1 | — | — | — | — | 1 |
| Colitis | D003092 | EFO_0003872 | K52.9 | 1 | — | — | — | — | 1 |
| Ulcer | D014456 | MPATH_579 | — | 1 | — | — | — | — | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | — | — | — | — | 1 |
| Recurrence | D012008 | — | — | 1 | — | — | — | — | 1 |
Show 8 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemic stroke | D000083242 | — | — | — | — | — | — | 3 | 3 |
| Vitamin k deficiency | D014813 | — | E56.1 | — | — | — | — | 3 | 3 |
| Micronutrients | D018977 | — | — | — | — | — | — | 2 | 2 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 2 | 2 |
| Aging | D000375 | GO_0007568 | R41.81 | — | — | — | — | 2 | 2 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | — | 1 | 1 |
| Gastrointestinal hemorrhage | D006471 | — | K92.2 | — | — | — | — | 1 | 1 |
| Renal insufficiency | D051437 | — | N19 | — | — | — | — | 1 | 1 |
| Fibrosis | D005355 | — | — | — | — | — | — | 1 | 1 |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | — | — | — | — | 1 | 1 |
Show 28 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Menadiol sodium diphosphate |
| INN | _ |
| Description | Kappadione, Synkayvite (menadiol sodium diphosphate) is a small molecule pharmaceutical. Menadiol sodium diphosphate was first approved as Kappadione on 1982-01-01. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(OP(=O)([O-])[O-])c2ccccc2c1OP(=O)([O-])[O-].O.O.O.O.O.O.[Na+].[Na+].[Na+].[Na+] |
Identifiers
| PDB | — |
| CAS-ID | 205-012-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989728 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 2OVL75B30W (ChemIDplus, GSRS) |
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